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Simple Randomization

In simple randomization, group membership is assigned by randomly selecting the group each subject will belong to according to a generalized Bernoulli distribution. Since each assignment is independant, this method does not guarantee balanced groups and long runs of the same group may occur. Unbalanced groups can reduce the power of hypothesis. This method is asymptotically balances so if the sample size is large, the result will be close to balances.

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References

  • M. Lachin, John, P. Matts, John & Wei, L.J. (1989), "Randomization in clinical trials: Conclusions and recommendations," Controlled clinical trials, 9, 365-74.
  • Suresh K. (2011), "An overview of randomization techniques: An unbiased assessment of outcome in clinical research," Journal of Human Reproductive Sciences, 4(1), 8-11.
  • Vickers AJ. (2006), "How to randomize," Journal of the Society for Integrative Oncology, 4(4), 194-198.